Inter-university cooperation across the world has shown several positive outcomes in terms of knowledge exchange as well as R&D benefits. This book portrays best practices of inter-university cooperation between Italian and American universities, while featuring agreements of Sapienza University of Rome. This book presents conceptual and implementation specifics of cooperation, policy perspectives, as well as a selection of framework agreements of current cooperation initiatives. Aimed at university professors, education and R&D policy makers, this book shall prove worthy as a guideline to initiate and implement inter-university cooperation globally.