This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks: a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity which will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling. Coding and software tools for systems biology. Covers the entire spectrum of modelling, from static networks, to dynamic models. Thoughtful exercises to test and enable student understanding of concepts. State-of-the-art chapters on exciting new developments, like whole-cell modelling and community modelling. The book is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.