In consultation with Consulting Editor, Dr. Bonita Stanton, Guest Editors Dr. Max J. Coppes and Dr. Leontien C.M. Kremer have created a unique issue of Pediatric Clinics of North America that addresses childhood cancer survival. Expert authors have contributed clinical reviews on the following topics: When childhood cancer becomes a family affair, it really hits home; What we know about survivors and how we know this: Early studies, early cohorts, registries and current cohorts of survivors; Radiotherapy and late effects; The critical role of clinical practice guidelines and indicators in high-quality survivorship after childhood cancer; Childhood cancer survivorship: Daily challenges; Psychological outcomes, health-related quality of life, and neurocognitive functioning in survivors of childhood cancer and their parents; Second cancer risk: Risk, exposures, genetics; Cardiovascular and pulmonary disease; Endocrine health in childhood cancer survivors; Reproductive complications in childhood cancer survivors; Renal and Hepatic Health after Childhood Cancer; Hearing and Other Neurologic Problems; The future of childhood cancer survivorship: Challenges and opportunities for continued progress. Readers will come away with the clinical information needed to improve outcomes in children with cancer.